Please combine Cover letter, Title page, Main manuscript, and Supplementary materials into one file and submit below. All author’s email, affiliation and funding information (if available) should be included in the title page. You will receive an email for confirmation after submission.

Important Notice: Thank you for considering Global Clinical and Translational Research for polishing your work. All submissions to the journal will be considered after peer-review for a publication under 1) authors assign copyright to the journal or 2) if the author chooses to open access under the Creative Commons Attribution License which allows anyone to copy, distribute or reuse the articles by properly citing the author and the original source. See more information at http://creativecommons.org/licenses/by/4.0/. Kindly remind that preparation of your manuscript should follow the  Instruction for Authors.