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Structured Benefit-Risk Assessments: An Illustrative Case Study of Paracetamol
Rosa A. Piccirillo and Jennifer Parish 2022/11/03 DOI: 10.36316/gcatr.04.0046. …
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Pharmacovigilance Principles: The Building Blocks of Benefit-Risk Assessments
Rosa A. Piccirillo and Jennifer Parish 2022/10/14 DOI:10.36316/gcatr.04.0045. A medicinal product must demonstrate a favorable benefit-risk balance to remain on the market. That the benefits…
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Metformin Combined LMWH Intervention in Pregnant Women with History of Hyperlipidemia Pancreatitis in Pregnancy
M Peng, YL Deng, L Yu, Y-T Nie, T Luo, J Huang, X-H Zhou, Y-L Ding 2021/07/15 DOI:10.36316/gcatr.03.0043 Objective: To explore the early preventive treatment of…
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IFN-γ Signaling in Lichen Planus
O Plazyo, S Shao, JE Gudjonsson 2021/03/21 DOI:10.36316/gcatr.03.0039 Lichen planus (LP) is a chronic inflammatory disease that affects the skin, nails, urogenital tract, and oral…
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Prevalence of Hypertension in Older and Middle-aged Adults in China
C Xia 2021/02/26 DOI:10.36316/gcatr.02.0034 Hypertension is a leading chronic risk for population health in China, especially for older and middle-aged adults. However, a representative estimate…
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Pathogen Genomics and Host Cellular Susceptibility Factors of COVID-19
F Zhang, MD Waters 2020/12/14 DOI:10.36316/gcatr.02.0037 Coronavirus disease 19 (COVID-19) caused by infection with a novel severe acute respiratory syndrome virus -2 (SARS-CoV2) has evolved…
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Clinical Characteristics of Coronavirus Disease 2019
X Qiu, Y Tian, X Jiang, J Xu, Q Zhang, J Huang 2020/10/11 Coronavirus Disease 2019 (COVID-19), a new respiratory disease caused by severe acute…
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Gut Microbiota and Antipsychotics Induced Metabolic Alteration
D Kang, S Li, C Liu, R Wu 2019/12/15 Schizophrenia is a chronic and severe mental disorder with antipsychotics as primary medications, but the antipsychotic-induced…
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Gut Microbiome in Autism Spectrum Disorder: Potential Mechanism and Implications for Clinical Intervention
Kuokuo Li , Zhengmao Hu, Jianjun Ou, Kun Xia Autism spectrum disorder is a heterogeneous neurodevelopmental disorder with an increased prevalence around the world over the past two decades. Remarkably, a…
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Childhood Adversity and Depression among Older Adults
Y Li, J Lu 6/19/2019 DOI:0.36316/gcatr.01.0007 This study examined the association of childhood adversity with depression or severity of depressive symptoms among Chinese older adults,…
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Preventive Management of Hypertriglyceridemia in Pregnancy: A Case Report
M Peng, J Huang, Y Ding 2020/02/26 Background: Hypertriglyceridemia in pregnancy is a rare but well-known cause of hypertriglyceridemia-induced acute pancreatitis (HTGP) in pregnancy, a life-threatening…
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Clinical Epidemiology of Coronavirus Disease 2019
F Zhang, C Hughes 2020/07/25 DOI:10.36316/gcatr.02.0032 Coronavirus disease 2019 (COVID-19) is a new infectious respiratory disease that has caused the ongoing global pandemic. The primary…
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A Caution in Association of ABO Blood Group with COVID-19
F Zhang, C Hughes 2020/06/10 DOI:10.36316/gcatr.02.0031