Claude Hughes and O Adibe

The incidence of gastroschisis has increased globally over recent decades, but the cause of this increase is not elucidated and etiology of gastroschisis has not been determined. Hughes and Adibe conducted a selective review of the literature on risk factors of gastroschisis including maternal illnesses, medication use, and substance abuse, environmental exposure or agricultural chemicals. They hypothesized two possible modes-of-action hypotheses: 1) mechanical forces – mechanosensitivity and mechanotransduction signaling, and 2) Ephrin-Eph receptor signaling, which could be highly attractive research and development opportunities, including preventive and mitigative intervention.

Reference:

Hughes C and Adibe O. The increasing prevalence of gastroschisis: associated factors, possible mechanisms, and potential mitigative interventions.  Glob Clin Transl Res. 2019; 1(1):4-20.Open Access